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OCR: oteins in T4 and T3 are largely bound to plasma ity for T4 the circulation. TBG has the greatest affi ne and T3, although a small proportion of to a lesser hormones also binds to prealbumin and ffinity, but extent, to albumin. Albumin has a low a ment of a large capacity, for T4 and T3. Measure itrations circulating total thyroid hormone conce ctions of includes both protein-bound and free fra ree the hormones (Fig. 15.11), although the 1% in the fractions represent a tiny proportion (0.0 ntration ofcase of T4) of the total. The normal conce 24pmol/l the free fraction of T4 lies between 9 and [4 (0.7 and 1.9ng/100ml), whereas the total lol/l concentration lies between 50 and 140nn n of free (4-11 ug/100ml). The normal concentrati T3 lies between 5 and 10pmol/1 (0.33 an en 1 and 0,65ng/100m ...